Anderson T L, Muttart C R, Bieber M A, Nicholson J F, Heird W C
J Pediatr. 1979 Jun;94(6):947-51. doi: 10.1016/s0022-3476(79)80230-9.
A controlled study comparing two intravenous fluid regimens was performed in sick, premature infants. The regimens were isocaloric at 60 calories/kg/day, one providing glucose alone, the other glucose plus 2.5 gm/kg of amino acids. There was no difference in changes in body weight between the two groups; infants receiving glucose alone were in negative nitrogen balance; those receiving glucose plus amino acids were in positive nitrogen balance. Plasma amino acid values were compared to published, postprandial normal values. The TEAA and TAA of infants receiving amino acids were not different from normal. Values of TEAA and TAA of infants receiving glucose alone were significantly lower. Essential fatty acid deficiency developed in infants receiving amino acids but not in those receiving glucose alone. It is concluded that the glucose plus amino acid regimen results in anabolism without undue metabolic costs.
在患病的早产儿中进行了一项比较两种静脉输液方案的对照研究。这两种方案的热量均为60卡路里/千克/天，一种仅提供葡萄糖，另一种提供葡萄糖加2.5克/千克的氨基酸。两组之间体重变化没有差异；仅接受葡萄糖的婴儿处于负氮平衡；接受葡萄糖加氨基酸的婴儿处于正氮平衡。将血浆氨基酸值与已发表的餐后正常值进行比较。接受氨基酸的婴儿的总必需氨基酸（TEAA）和总氨基酸（TAA）与正常水平无异。仅接受葡萄糖的婴儿的TEAA和TAA值显著更低。接受氨基酸的婴儿出现了必需脂肪酸缺乏，而仅接受葡萄糖的婴儿未出现。结论是，葡萄糖加氨基酸方案可促进合成代谢，且不会产生过多的代谢成本。
