Jia Xin-Yu, Wu Yong-Mei, Li Jing-Ya, Lei Chun, Hou Ai-Jun
School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201203, China.
National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Nat Prod Bioprospect. 2020 Feb;10(1):45-49. doi: 10.1007/s13659-020-00233-5. Epub 2020 Feb 18.
Four new alkaloids, ficuhismines A-D (1-4), together with three known ones, were isolated from Ficus hispida. Their structures were elucidated by spectroscopic analysis and chemical method. The new compounds represent the first amine alkaloids with a rhamnosyl moiety (1-2) or with a N-oxide motif (2-4) from the genus Ficus. Compound 2 showed potent inhibitory effect in nuclear factor-κB (NF-κB) pathway luciferase assay with IC value of 0.52 ± 0.11 μM.
从榕树中分离出四种新生物碱，即榕皮胺A-D（1-4），以及三种已知生物碱。通过光谱分析和化学方法阐明了它们的结构。这些新化合物代表了榕属植物中首个带有鼠李糖基部分（1-2）或带有N-氧化物基序（2-4）的胺类生物碱。化合物2在核因子-κB（NF-κB）途径荧光素酶测定中显示出强效抑制作用，IC值为0.52±0.11μM。
