静脉注射泼尼松龙治疗慢性支气管哮喘
Intravenous prednisolone in chronic bronchial asthma.
作者信息
Ellul-Micallef R, Fenech F F
出版信息
Thorax. 1975 Jun;30(3):312-5. doi: 10.1136/thx.30.3.312.
Abstract
A single injection of 40 mg prednisolone phosphate was given to 10 patients with chronic bronchial asthma. Changes in pulmonary function were followed over a 30-hour period. Statistically significant changes occurred in the tests employed one hour after the injection of prednisolone. The maximum change for the group as a whole was seen to occur after eight hours. This time course of response is very similar to that obtained in previous studies on similar groups of patients with oral prednisolone where the peak effect occurred nine hours after the drug had been given. Intravenous hydrocortisone produces a much earlier peak effect, at five hours, when it is administered to chronic asthmatic patients.
摘要
对10例慢性支气管哮喘患者单次注射40mg磷酸泼尼松龙。在30小时内跟踪观察肺功能变化。注射泼尼松龙1小时后所采用的测试中出现了具有统计学意义的变化。整个组的最大变化出现在8小时后。这种反应的时间过程与之前对类似患者组口服泼尼松龙的研究结果非常相似，在给药后9小时出现峰值效应。当对慢性哮喘患者静脉注射氢化可的松时，其峰值效应出现得更早，在5小时。
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本文引用的文献
1
Effects of cortisone on bronchial asthma and hay fever occurring in subjects sensitive to ragweed pollen.
Proc Staff Meet Mayo Clin. 1950 Aug 16;25(17):482-6.
2
Clinical value of the forced expiratory time measured during auscultation.听诊时测量的用力呼气时间的临床价值。
N Engl J Med. 1962 Aug 30;267:432-5. doi: 10.1056/NEJM196208302670903.
3
Metabolism of adrenocorticosteroids in man.人类肾上腺皮质类固醇的代谢
Ann N Y Acad Sci. 1959 Oct 14;82:846-53. doi: 10.1111/j.1749-6632.1960.tb44966.x.
4
Maximum forced expiratory flow rate as a measure of ventilatory capacity: with a description of a new portable instrument for measuring it.作为通气能力指标的最大用力呼气流量率：并介绍一种测量该指标的新型便携式仪器。
Br Med J. 1959 Nov 21;2(5159):1041-6. doi: 10.1136/bmj.2.5159.1041.
5
Absorption of steroid hormones from the human small intestine.
J Clin Endocrinol Metab. 1965 Oct;25(10):1309-16. doi: 10.1210/jcem-25-10-1309.
6
Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma.苯巴比妥对支气管哮喘患者皮质类固醇代谢的不良影响。
N Engl J Med. 1972 May 25;286(21):1125-8. doi: 10.1056/NEJM197205252862103.
7
Effect of diphenylhydantoin on the metabolism of dexamethasone.
N Engl J Med. 1970 Jul 2;283(1):11-4. doi: 10.1056/NEJM197007022830103.
8
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