Luksza A R, Jones D K
Br Med J (Clin Res Ed). 1982 Oct 30;285(6350):1229-31. doi: 10.1136/bmj.285.6350.1229.
Venous whole-blood eosinophil counts were performed on 50 occasions in 42 patients with varying patterns of asthma. None of the patients studied had received systemic corticosteroids during the previous year. Patients with acute severe asthma, as defined by symptomatic airways obstruction with a tachycardia of at least 120 beats/min, showed eosinopenia (21 x 10(9)/l +/- SD 57 x 10(9)/l). Patients with chronic asthma, as defined by symptomatic airways obstruction with a heart rate of less than 100 beats/min, showed appreciable eosinophilia (1048 x 10(9)/l +/- SD 708 x 10(9)/l). Finally, asymptomatic patients had a variable total eosinophil count but with values lower than those of patients with chronic asthma (345 x 10(9)/l +/- SD 431 x 10(9)/l). Eosinophilia may contain chronic asthma, thereby mediating bronchial damage, whereas absence of eosinophils in acute asthma enables vasoactive mediators to enter the systemic circulation, possibly causing circulatory disturbances.
对42例哮喘症状各异的患者进行了50次静脉全血嗜酸性粒细胞计数。所有研究对象在过去一年中均未接受过全身性皮质类固醇治疗。根据症状性气道阻塞且心率至少为120次/分钟定义的急性重症哮喘患者表现为嗜酸性粒细胞减少（21×10⁹/L±标准差57×10⁹/L）。根据症状性气道阻塞且心率低于100次/分钟定义的慢性哮喘患者表现出明显的嗜酸性粒细胞增多（1048×10⁹/L±标准差708×10⁹/L）。最后，无症状患者的嗜酸性粒细胞总数各不相同，但数值低于慢性哮喘患者（345×10⁹/L±标准差431×10⁹/L）。嗜酸性粒细胞增多可能与慢性哮喘有关，从而介导支气管损伤，而急性哮喘中缺乏嗜酸性粒细胞会使血管活性介质进入体循环，可能导致循环紊乱。
