Stathopoulos C, Hendrixson D R, Thanassi D G, Hultgren S J, St Geme J W, Curtiss R
Department of Biology, Washington University, One Brookings Drive, St. Louis, MO 63110, USA.
Microbes Infect. 2000 Jul;2(9):1061-72. doi: 10.1016/s1286-4579(00)01260-0.
Secretion of proteins by the general secretory pathway (GSP) is a two-step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence.
通过通用分泌途径（GSP）分泌蛋白质是一个两步过程，需要内膜中的Sec转位酶和一个单独的底物特异性分泌装置来跨外膜转运。具有致病潜力的革兰氏阴性菌利用GSP将毒力因子传递到细胞外环境中以与宿主相互作用。利用GSP进行分泌的毒力决定因素的深入研究实例包括细胞外毒素、菌毛、卷曲菌毛、自转运蛋白和结晶S层。本文综述了我们目前对GSP的理解，并讨论了与细菌毒力相关的因子所利用的GSP末端分支的实例。
