Costa T R, Fernandes O F, Santos S C, Oliveira C M, Lião L M, Ferri P H, Paula J R, Ferreira H D, Sales B H, Silva M do R
Departamento de Microbiologia, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, 74605-050 Goiânia, GO, Brazil.
J Ethnopharmacol. 2000 Sep;72(1-2):111-7. doi: 10.1016/s0378-8741(00)00214-2.
The essential oil from the hydrodistillation of Eugenia dysenterica leaves consisted mainly of beta-caryophyllene and alpha-humulene as the major sesquiterpene, while limonene and alpha-thujene were the major monoterpene hydrocarbons. The main oxygenated mono and sesquiterpene constituents were alpha-terpineol and beta-caryophyllene oxide, respectively. The oil was investigated against eight strains of Candida albicans, 35 strains of Cryptococcus neoformans var. neoformans, and two C. neoformans var. gattii isolated from HIV-infected individuals with candidosis or cryptococcal meningitis using the agar dilution method. Based on the minimal inhibitory concentration (MIC) values, the most significant results were obtained against Cryptococcus strains. It was observed that 22 strains were inhibited at a concentration of 250 microg/ml, whereas four exhibited potent inhibition with MIC values below 125 microg/ml against 10(6) UFC/ml organisms. We found MICs > or = 3.12 microg/ml for 91.6, 50 and 30% of all Cryptococcus strains in relation of amphotericin B, fluconazole and itraconazole, respectively.
从痢疾番樱桃叶水蒸馏得到的精油主要由β-石竹烯和α-葎草烯作为主要倍半萜烯组成，而柠檬烯和α-侧柏烯是主要的单萜烃类。主要的含氧单萜和倍半萜成分分别是α-松油醇和β-石竹烯氧化物。使用琼脂稀释法，对该精油针对8株白色念珠菌、35株新型隐球菌新型变种以及从患有念珠菌病或隐球菌性脑膜炎的HIV感染者中分离出的2株新型隐球菌加蒂变种进行了研究。基于最低抑菌浓度（MIC）值，针对隐球菌菌株获得了最显著的结果。观察到22株在250微克/毫升的浓度下受到抑制，而有4株对每毫升10(6)个菌落形成单位的生物体表现出MIC值低于125微克/毫升的强效抑制。我们发现，与两性霉素B、氟康唑和伊曲康唑相比，分别有91.6%、50%和30%的所有隐球菌菌株的MIC≥3.12微克/毫升。
