Khoo K L, Tan H, Liew Y M
Pantai Medical Centre, Kuala Lumpur.
Med J Malaysia. 1997 Mar;52(1):38-52.
Over a thousand subjects who visited a city private medical clinic for health screening and advice were examined for their lipid profile and other cardiovascular risk factors. The mean TC, TG, LDL-C and HDL-C were 5.43, 1.45, 3.61 and 1.15 mmol/l. Their derived ratios viz, TC:HDL-C and LDL:HDL-C were 5.11 and 3.43 respectively. The prevalence of hyperlipidaemia was moderately high. Of the subjects studied 58.5% had elevated serum cholesterol, 14.8% had raised triglycerides, 64.9% had raised LDL-C and 20.8% had low HDL-C. Male subjects generally showed higher mean values and abnormality frequency in TC, TG, LDL-C, TC:HDL-C and LDL:HDL-C as compared to female subjects. Although significant ethnic differences were not detected for certain lipid parameters (e.g. TC, TG and HDL-C), the Indians appeared to have higher mean lipid values (except HDL-C), and higher percentage abnormality for all the lipid parameters as compared to the Chinese and the Malays. In correlation studies, the following lipid parameters:- TC versus TG, LDL-C, TC:HDL-C; TG versus TC:HDL-C and LDL:HDL-C; LDL-C versus TC:HDL-C and LDL:HDL-C; were positively correlated. On the other hand, TC versus HDL-C, TG versus HDL-C, LDL-C and HDL-C, and HDL-C versus TC:HDL-C and LDL:HDL-C were negatively correlated. The coronary risk factors which generally showed positive correlations with lipid parameters were BMI and blood pressure. Positive correlations were also recorded between fasting blood glucose and TG; uric acid with TG, TC:HDL-C and LDL:HDL-C. In contrast, risk factors of negative correlations were observed between HDL-C and the coronary risk factors of BMI, diastolic blood pressure and uric acid. Smoking showed raised per cent lipid abnormality for TG, HDL-C, TC:HDL-C and LDL:HDL-C. Alcohol consumption also increased the mean level and abnormality frequency for TG. The implication of this investigation is discussed.
一千多名前往一家城市私人医疗诊所进行健康筛查和咨询的受试者接受了血脂水平及其他心血管危险因素的检查。总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的均值分别为5.43、1.45、3.61和1.15毫摩尔/升。其衍生比值，即TC:HDL-C和LDL:HDL-C分别为5.11和3.43。高脂血症的患病率处于中等偏高水平。在研究的受试者中，58.5%的人血清胆固醇升高，14.8%的人甘油三酯升高，64.9%的人LDL-C升高，20.8%的人HDL-C降低。与女性受试者相比，男性受试者在TC、TG、LDL-C、TC:HDL-C和LDL:HDL-C方面的均值和异常频率普遍较高。尽管在某些血脂参数（如TC、TG和HDL-C）方面未检测到显著的种族差异，但与华人和马来人相比，印度人似乎具有更高的血脂均值（HDL-C除外），并且所有血脂参数的异常百分比更高。在相关性研究中，以下血脂参数之间存在正相关：TC与TG、LDL-C、TC:HDL-C；TG与TC:HDL-C和LDL:HDL-C；LDL-C与TC:HDL-C和LDL:HDL-C。另一方面，TC与HDL-C、TG与HDL-C、LDL-C与HDL-C，以及HDL-C与TC:HDL-C和LDL:HDL-C之间存在负相关。通常与血脂参数呈正相关的冠心病危险因素是体重指数（BMI）和血压。空腹血糖与TG之间、尿酸与TG、TC:HDL-C和LDL:HDL-C之间也记录到了正相关。相比之下，在HDL-C与BMI、舒张压和尿酸等冠心病危险因素之间观察到了负相关。吸烟显示TG、HDL-C、TC:HDL-C和LDL:HDL-C的脂质异常百分比升高。饮酒也增加了TG的平均水平和异常频率。本文讨论了该调查的意义。
