Counahan R, Mearns M B
Arch Dis Child. 1975 Jun;50(6):477-81. doi: 10.1136/adc.50.6.477.
Skin tests and exercise tests were performed on children with cystic fibrosis (CF) and first-degree relatives of CF children. Positive skin tests were found in 56% of patients and 19% of relatives, but the prevalence of atopy in CF patients bore no relationship to its prevalence in their relatives. Increased 0ronchial lability, mainly due to bronchoconstriction, was present in 54% of patients and 27% of relatives. The results showed that increased prevalence of bronchial lability, but not atopy, is found in first-degree relatives of CF children, and that the abnormal lability and atopy found in CF children does not indicate a familial allergic background.
对患有囊性纤维化（CF）的儿童及其CF患儿的一级亲属进行了皮肤试验和运动试验。56%的患者和19%的亲属皮肤试验呈阳性，但CF患者中特应性的患病率与其亲属中的患病率无关。54%的患者和27%的亲属存在支气管易激性增加，主要是由于支气管收缩所致。结果表明，CF患儿的一级亲属中支气管易激性增加的患病率较高，但特应性并非如此，且CF患儿中发现的异常易激性和特应性并不表明存在家族性过敏背景。
