Loughlin G M, Cota K A, Taussig L M
Chest. 1981 Feb;79(2):206-10. doi: 10.1378/chest.79.2.206.
Patients with cystic fibrosis (CF), in contrast to asthmatic subjects, often show a larger increase than decrease (bronchial lability) in peak flows following exercise. Children with CF also often have large supramaximal expiratory flow transients, produced by rapid expulsion of air from conducting airways that are being dynamically compressed. We studied the relationship between bronchial lability and flow transients to explain the peculiar form of bronchial lability found in certain CF patients. At baseline, six of seven CF patients had flow transients, suggestive of decreased resting tone of the conducting airways. Following exercise, there was a strong positive correlation (r = 0.76, P less than .01) between changes in peak flow and changes in the volume of the flow transients. Four subjects increased both, two did not change either, and in one subject both peak flow and the volume of the flow transient decreased. This study suggests that the unique, previously unexplained form of postexercise bronchial lability observed in some CF patients is probably due mainly to flow transients that contribute to peak flows. These transients are probably related to increased compliance of the conducting airways in this disease.
与哮喘患者不同，囊性纤维化（CF）患者在运动后峰值流量往往增加幅度大于下降幅度（支气管易激性）。CF患儿还常常出现超大呼气流量瞬变，这是由动态受压的传导气道快速排出空气所致。我们研究了支气管易激性与流量瞬变之间的关系，以解释在某些CF患者中发现的特殊形式的支气管易激性。在基线时，7名CF患者中有6名出现流量瞬变，提示传导气道静息张力降低。运动后，峰值流量变化与流量瞬变体积变化之间存在强正相关（r = 0.76，P < 0.01）。4名受试者两者均增加，2名受试者两者均无变化，1名受试者峰值流量和流量瞬变体积均下降。这项研究表明，一些CF患者运动后出现的独特的、以前无法解释的支气管易激性形式可能主要是由于对峰值流量有贡献的流量瞬变。这些瞬变可能与该疾病中传导气道顺应性增加有关。
