囊性纤维化与过敏的关联。
Association of cystic fibrosis with allergy.
作者信息
Warner J O, Taylor B W, Norman A P, Soothill J F
出版信息
Arch Dis Child. 1976 Jul;51(7):507-11. doi: 10.1136/adc.51.7.507.
Abstract
Immediate skin hypersensitivity to various inhalant allergens was present in 59% of 123 children with cystic fibrosis (CF), a much higher percentage than in the general population. This is consistent with the idea that atopy arises as a result of impaired handling of antigen at mucosal surfaces. The allergic CF children had more chest infections, a worse chest x-ray appearance, and lower peak expiratory flow rates. Allergic diseases were also frequent in the CF obligate heterozygotes (32% of mothers and 26% of fathers). It is suggested that the heterozygotes may also have a mucosal abnormality resulting in defective antigen handling.
摘要
123名囊性纤维化（CF）患儿中，59%对多种吸入性过敏原存在即刻皮肤超敏反应，这一比例远高于普通人群。这与特应性是由于黏膜表面对抗原处理受损而产生的观点一致。患过敏性疾病的CF患儿有更多的胸部感染、胸部X光表现更差且呼气峰值流速更低。CF基因携带者（母亲中的32%和父亲中的26%）也常有过敏性疾病。研究表明，基因携带者可能也存在黏膜异常，导致对抗原的处理存在缺陷。
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