Immunodeficiency and autoimmunity.

The following aspects of autoimmunity and immunodeficiency will be discussed: 1) Autoantibodies and autoimmunity and their relationships to human disease and particularly to the rheumatic diseases. 2) Relationships between human immunodeficiency diseases and autoimmunity including: a) autoimmune disease in patients with immunodeficiency; b) arthritis in patients with immunodeficiency; c) lupus-like illness in carriers of chronic granulomatous disease; d) occurrence of autoantibodies and autoimmunity in relatives of patients with immunodeficiency. 3) Immunodeficiency as a basis for human rheumatic or autoimmune diseases. The role of immunodeficiency in NZB mouse diseases and human SLE. 4) The role of viral infections in autoimmune disease.