通过子代检测研究NZB小鼠自身免疫的遗传基础。
The genetic basis of autoimmunity in NZB mice studied by progeny-testing.
作者信息
Ghaffar A, Playfair J H
出版信息
Clin Exp Immunol. 1971 Mar;8(3):479-90.
Abstract
NZB mice were mated to NZW and to Balb/c, and the F, F and backcross progeny tested for the incidence of red-cell autoantibodies, glomerulonephritis, and anti-nuclear antibodies. Evidence was found for some segregation of these autoimmune characteristics, and the results were interpreted as favouring an underlying genetic basis, though not a simple one.
摘要
将新西兰黑鼠（NZB）与新西兰白兔（NZW）以及与巴氏小鼠（Balb/c）进行交配，并对其F1、F2和回交后代检测红细胞自身抗体、肾小球肾炎和抗核抗体的发生率。发现这些自身免疫特征存在一些分离现象，结果被解释为支持存在潜在的遗传基础，尽管并非简单的遗传基础。
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