Duignan N M, Shaw R W, Rudd B T, Holder G, Williams J W, Butt W R, Logan-Edwards R, London D R
Clin Endocrinol (Oxf). 1975 May;4(3):287-95. doi: 10.1111/j.1365-2265.1975.tb01536.x.
The response to synthetic luteinizing hormone-releasing hormone was studied in eighteen patients with the polycystic ovary syndrome. The release of follicle-stimulating hormone was similar to that found in normal women. The mean response of luteinizing hormone was similar to that found in the luteal phase, but significantly greater (P less than 0-02) than that found in the early follicular phase of the normal menstrual cycle. Basal serum levels of FSH and LH, estimated in twenty-five patients, were similar to those found in normal subjects. The sex hormone binding globulin capacity was reduced in twenty-four of them. Basal serum testosterone levels were elevated in twelve of twenty-two patients and the mean level was significantly greater (P less than 0-01) than the mean level of normal women. Basal serum androstenecione levels were elevated in nine of twenty-two patients and the mean level was also significantly greater (P leess than 0-001) between basal testosterone and LH levels. These data suggest the pituitary gland of patients with the polycystic ovary syndrome contains adequate amounts of LH but that the ovulatory surge of LH which occurs in normal women is inhibited by testosterone acting on either the pituitary or, more probably, on the hypothalamus.
对18例多囊卵巢综合征患者进行了合成促黄体生成激素释放激素反应的研究。促卵泡生成素的释放与正常女性相似。促黄体生成素的平均反应与黄体期相似，但显著高于（P小于0.02）正常月经周期卵泡早期的反应。对25例患者测定的基础血清促卵泡生成素（FSH）和促黄体生成素（LH）水平与正常受试者相似。其中24例患者的性激素结合球蛋白能力降低。22例患者中有12例基础血清睾酮水平升高，平均水平显著高于（P小于0.01）正常女性的平均水平。22例患者中有9例基础血清雄烯二酮水平升高，基础睾酮水平与LH水平之间的平均水平也显著更高（P小于0.001）。这些数据表明，多囊卵巢综合征患者的垂体含有足够量的LH，但正常女性出现的LH排卵高峰受到睾酮对垂体或更可能是对下丘脑的作用的抑制。
