Chetty R
Division of Anatomical Pathology, University of Natal School of Pathology and Laboratory Medicine, Durban, South Africa.
Histopathology. 2000 Sep;37(3):260-3. doi: 10.1046/j.1365-2559.2000.00976.x.
The aims of this study were to ascertain the incidence of intercalated duct hyperplasia in association with cases of epithelial-myoepithelial carcinoma (EMC), and to explore a possible relationship between them and hybrid carcinomas of salivary glands.
Seven cases of EMC with sufficient surrounding non-tumour parotid were examined. Three cases contained foci of intercalated duct hyperplasia adjacent to the tumour. One of the cases was a hybrid tumour composed of EMC and mucoepidermoid carcinoma. The hyperplastic intercalated ducts formed multiple foci within the salivary parenchyma and were composed of bland, uniform ducts. Cytological atypia was not identified.
Intercalated duct hyperplasia may be a precursor lesion to EMC. Furthermore, it may also explain why EMC is frequently associated with other salivary gland carcinomas, so-called hybrid tumours, as well as sharing histological features with adenoid cystic carcinoma. Recognition of the latter is of particular importance because adenoid cystic carcinoma carries a poor prognosis.
本研究旨在确定闰管增生与上皮-肌上皮癌（EMC）病例相关的发生率，并探讨它们与涎腺混合癌之间可能存在的关系。
对7例伴有足够周围非肿瘤腮腺组织的EMC病例进行检查。3例在肿瘤附近含有闰管增生灶。其中1例为EMC和黏液表皮样癌组成的混合瘤。增生的闰管在涎腺实质内形成多个病灶，由形态温和、均匀一致的导管构成。未发现细胞异型性。
闰管增生可能是EMC的前驱病变。此外，它还可能解释为什么EMC常与其他涎腺癌（即所谓的混合瘤）相关，以及与腺样囊性癌具有共同的组织学特征。认识到后者尤为重要，因为腺样囊性癌预后较差。
