Ivanov A P, Dekonenko A E, Dzagurova T K, Malkin A E, Shervarli V I, Baranovskiĭ P M, Vardanian N V, Bulanov V E, Nikolaeva E I, Tkachenko E A
Vopr Virusol. 2000 Jul-Aug;45(4):33-6.
Epizootological, serological, and molecular virological analysis of an outbreak of hemorrhagic fever with renal syndrome (HFRS) in the Egoryevsk district of Moscow region (September 1995-January 1996) has been carried out. Hantavirus (Puumala) antigen and virus-specific antibodies were isolated from bank voles captured in the endemic focus. Anti-Puumala antibodies were detected in the sera of all HFRS patients and in 2% healthy residents of the endemic focus. Analysis of nucleotide sequence (RNA from hantavirus-positive lung of a bank vole) showed that the studied hantavirus is a distinct genotype of Puumala virus. Hence, a new highly active natural focus of HFRS associated with Puumala virus, dangerous for the population, has been revealed in Moscow region.
对莫斯科地区叶戈里耶夫斯克区1995年9月至1996年1月爆发的肾综合征出血热（HFRS）疫情进行了流行病学、血清学和分子病毒学分析。从流行疫源地捕获的棕背鼠平中分离出汉坦病毒（普马拉型）抗原和病毒特异性抗体。在所有HFRS患者的血清以及流行疫源地2%的健康居民血清中检测到抗普马拉抗体。对核苷酸序列（来自汉坦病毒阳性棕背鼠平肺组织的RNA）的分析表明，所研究的汉坦病毒是普马拉病毒的一个独特基因型。因此，在莫斯科地区发现了一个新的与普马拉病毒相关的、对人群有危险的HFRS高活性自然疫源地。
