Goerss A L, Wagner G C, Hill W L
Department of Psychology, Lafayette College, Easton, PA 18042, USA.
Life Sci. 2000 Aug 4;67(11):1325-9. doi: 10.1016/s0024-3205(00)00723-2.
The inverse relationship between serotonin and aggression was investigated in rats treated with aspartame, a sweetener thought to interfere with the synthesis of this neurotransmitter. Eleven adult, male Long-Evans rats received either aspartame (200-800 mg/kg, IP) or the vehicle prior to testing in a standard resident-intruder paradigm. Contrary to our hypothesis, aspartame significantly decreased aggression as shown by increased latencies to the first attack and decreased number of bites per session. Corresponding with the effects on aggression, aspartame significantly increased striatal levels of serotonin. It was concluded that high doses of aspartame reduced aggressive attack via a serotonergic mechanism while the lower dose was without effect on either variable.
在接受阿斯巴甜治疗的大鼠中研究了血清素与攻击性之间的反向关系。阿斯巴甜是一种甜味剂，被认为会干扰这种神经递质的合成。在标准的领地-入侵者范式测试之前，11只成年雄性Long-Evans大鼠接受了阿斯巴甜（200-800毫克/千克，腹腔注射）或赋形剂。与我们的假设相反，阿斯巴甜显著降低了攻击性，表现为首次攻击的潜伏期延长和每次试验咬的次数减少。与对攻击性的影响相对应，阿斯巴甜显著提高了纹状体中血清素的水平。得出的结论是，高剂量的阿斯巴甜通过血清素能机制减少了攻击性攻击，而低剂量对这两个变量均无影响。
