Velasco F, Velasco M, Estrada-Villanueva F, Machado J P
Epilepsia. 1975 Jun;16(2):207-14. doi: 10.1111/j.1528-1157.1975.tb06049.x.
A quantitative evaluation of specific and nonspecific multiple unit activity (MUA) before and during pentylenetetrazol-induced EEG tonic-clonic discharges (OTCD) was made at four levels of the CNS: cortical, thalamic, mesencephalic, and pontine. In addition, MUA of sciatic nerve was recorded to detect possible spinal cord efferent discharges. At all levels, sustained increase in specific and nonspecific multiple unit activity preceded EEG and sciatic nerve discharges induced by pentylenetetrazol. Increments in nonspecific MUA occurred sooner and were larger than those of specific MUA, and increments in mesencephalic nonspecific MUA occurred sooner and were larger than those of other cortical, thalamic, and pontine nonspecific MUAs. This sequence of neuronal activation suggests that pentylenetetrazol seizures are initiated in nonspecific structures at the mesencephalic level.
在中枢神经系统的四个水平（皮层、丘脑、中脑和脑桥）对戊四氮诱发脑电图强直阵挛性放电（OTCD）之前和期间的特异性和非特异性多单位活动（MUA）进行了定量评估。此外，记录坐骨神经的MUA以检测可能的脊髓传出放电。在所有水平上，戊四氮诱发的脑电图和坐骨神经放电之前，特异性和非特异性多单位活动持续增加。非特异性MUA的增加出现得更早且幅度大于特异性MUA，中脑非特异性MUA的增加出现得更早且幅度大于其他皮层、丘脑和脑桥非特异性MUA。这种神经元激活顺序表明，戊四氮惊厥在中脑水平的非特异性结构中起始。
