Powell W A, Catranis C M, Maynard C A
SUNY, College of Environmental Science and Forestry, Syracuse, NY 13210-2788, USA.
Lett Appl Microbiol. 2000 Aug;31(2):163-8. doi: 10.1046/j.1365-2672.2000.00782.x.
Small antimicrobial peptides are excellent candidates for inclusion in self-processing proteins that could be used to confer pathogen resistance in transgenic plants. Antimicrobial peptides as small as 22 amino acids in length have been designed to incorporate the residual amino acids left from protein processing by the tobacco etch virus'(TEVs') NIa protease. Also, by minimizing the length of these peptides and the number of highly hydrophobic residues, haemolytic activity was reduced without affecting the peptide's antimicrobial activity.
小型抗菌肽是自加工蛋白中用于赋予转基因植物病原体抗性的优秀候选物。长度仅为22个氨基酸的抗菌肽已被设计用于整合烟草蚀纹病毒（TEV）NIa蛋白酶进行蛋白质加工后留下的残余氨基酸。此外，通过最小化这些肽的长度和高疏水性残基的数量，溶血活性降低，而不影响肽的抗菌活性。
