Hoshino N, Kimura T, Hayakawa F, Yamaji A, Ando T
Department of Pharmacy, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan.
Lett Appl Microbiol. 2000 Sep;31(3):213-7. doi: 10.1046/j.1365-2672.2000.00800.x.
The bactericidal activity of catechin-copper (II) complexes against Staphylococcus aureus compared with Escherichia coli was investigated in relation to the generation of hydrogen peroxide and the binding of Cu(II) ion onto the bacteria. The bactericidal activity of catechin-Cu(II) complexes against Staph. aureus (Gram-positive) was much lower than that against E. coli (Gram-negative), suggesting that the binding of copper ions to the surface of bacterial cells plays an important role in the bactericidal activity of catechin-Cu(II) complexes.
研究了儿茶素 - 铜（II）配合物对金黄色葡萄球菌和大肠杆菌的杀菌活性，并探讨了其与过氧化氢生成以及铜（II）离子与细菌结合的关系。儿茶素 - 铜（II）配合物对金黄色葡萄球菌（革兰氏阳性菌）的杀菌活性远低于对大肠杆菌（革兰氏阴性菌）的杀菌活性，这表明铜离子与细菌细胞表面的结合在儿茶素 - 铜（II）配合物的杀菌活性中起重要作用。
