Gross N T, Jarstrand C, Robertson B
Division of Clinical Bacteriology, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge Hospital, Huddinge, Sweden.
Lett Appl Microbiol. 2000 Sep;31(3):218-22. doi: 10.1046/j.1365-2672.2000.00790.x.
Cryptococcosis in AIDS patients has a slow response to antifungal chemotherapy, and passive antibody treatment has thus been considered as an adjunct. Polyclonal anticryptococcal IgG dissolved in a suspension of modified natural surfactant was given intratracheally to near-term rabbits. Killing of Cryptococcus neoformans within the lungs was determined by counting the colony forming units (cfu). After 5 h a significant decrease in cfu was observed in rabbits treated with the IgG-surfactant mixture compared with control animals receiving saline. In conjunction with conventional therapy, the combined treatment of IgG-surfactant given by bronchoscopy might be used in high-risk patients to enhance killing of the yeast within the lungs.
艾滋病患者的隐球菌病对抗真菌化疗反应缓慢，因此被动抗体治疗被视为一种辅助治疗方法。将溶解于改良天然表面活性剂悬浮液中的多克隆抗隐球菌IgG经气管内给予近足月的兔子。通过计数菌落形成单位（cfu）来确定肺内新型隐球菌的杀灭情况。5小时后，与接受生理盐水的对照动物相比，用IgG-表面活性剂混合物治疗的兔子cfu显著减少。结合传统疗法，通过支气管镜给予IgG-表面活性剂的联合治疗可用于高危患者，以增强肺内酵母的杀灭效果。
