Roeder G S, Bailis J M
Howard Hughes Medical Institute, Yale University, PO Box 208103, New Haven, CT 06520-8103, USA.
Trends Genet. 2000 Sep;16(9):395-403. doi: 10.1016/s0168-9525(00)02080-1.
The pachytene checkpoint prevents meiotic nuclear division in cells that fail to complete meiotic recombination and chromosome synapsis. This control mechanism prevents chromosome missegregation that would lead to the production of aneuploid gametes. The pachytene checkpoint requires a subset of proteins that function in the mitotic DNA damage checkpoint. In budding yeast, the pachytene checkpoint also requires meiosis-specific chromosomal proteins and, unexpectedly, proteins concentrated in the nucleolus. Progress has been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint.
粗线期检查点可防止未能完成减数分裂重组和染色体联会的细胞进行减数分裂核分裂。这种控制机制可防止染色体错分离，而染色体错分离会导致非整倍体配子的产生。粗线期检查点需要一组在有丝分裂DNA损伤检查点中发挥作用的蛋白质。在芽殖酵母中，粗线期检查点还需要减数分裂特异性染色体蛋白，并且出乎意料的是，还需要集中在核仁中的蛋白质。在确定受该检查点影响的细胞周期机制成分方面已经取得了进展。
