Ronsini M L, Collares E F
Núcleo de Medicina e Cirurgia Experimental, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.
Braz J Med Biol Res. 2000 Sep;33(9):1047-51. doi: 10.1590/s0100-879x2000000900009.
The effects of adrenalectomy and adrenal enucleation on liquid gastric emptying were studied in male Wistar rats that were adrenalectomized, adrenal enucleated (AE) or sham operated (SH). The animals in the first group had free access to a 1% NaCl solution (ADS), while the animals in the second and third groups were divided into two subgroups, which ingested either tap water (AEW, SHW) or 1% NaCl solution (AES, SHS). The gastric emptying study was performed on the 16th post-operative day. Three test meals labeled with phenol red (6 mg/dl) were used (0.9% NaCl, 1.8% NaCl and 5% glucose). Percent gastric retention was determined 10 min after orogastric infusion of the NaCl test meals and 15 min after the glucose meal. Gastric retention of the ADS subgroup was significantly lower (P<0. 01) (median = 19.8% vs 25.5% for SHW, vs 31.9% for SHS, vs 25.7% for AEW, and vs 27.1% for AES) for the 0.9% NaCl test meal and for the 1. 8% NaCl test meal (33.5% for ADS vs 47.5% for AEW and 50.6% for AES). When 5% glucose was used as a test meal, gastric retention was similar for all subgroups. These results suggest that ablation of the adrenal cortex results in increased gastric emptying of an isosmolar NaCl meal.
在接受肾上腺切除术、肾上腺摘除术（AE）或假手术（SH）的雄性Wistar大鼠中，研究了肾上腺切除术和肾上腺摘除术对液体胃排空的影响。第一组动物可自由饮用1%的氯化钠溶液（ADS），而第二组和第三组动物被分为两个亚组，分别摄入自来水（AEW、SHW）或1%的氯化钠溶液（AES、SHS）。在术后第16天进行胃排空研究。使用了三种用酚红标记（6毫克/分升）的测试餐（0.9%氯化钠、1.8%氯化钠和5%葡萄糖）。在经口胃内注入氯化钠测试餐后10分钟和注入葡萄糖餐后15分钟测定胃潴留百分比。对于0.9%氯化钠测试餐和1.8%氯化钠测试餐，ADS亚组的胃潴留显著降低（P<0.01）（中位数=19.8%，SHW为25.5%，SHS为31.9%，AEW为25.7%，AES为27.1%）；使用5%葡萄糖作为测试餐时，所有亚组的胃潴留相似。这些结果表明，肾上腺皮质的切除导致等渗氯化钠餐的胃排空增加。
