Gett A V, Hodgkin P D
Immune Regulation Group, Medical Foundation, University of Sydney, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Sydney 2042 NSW, Australia.
Nat Immunol. 2000 Sep;1(3):239-44. doi: 10.1038/79782.
During an immune response numerous receptor-mediated signals delivered to T cells direct their proliferation, survival and differentiation. Here, we describe a quantitative model and in vitro methods for assessing the "calculus" used by T cells to process these multiple signals. The model reveals how T cells convert independently received signals into linear additive effects on division times which, in turn, amplify T cell number exponentially. These results explain why so many ligands can each appear obligatory for T cell activation and argue for a re-examination of the two-signal theory as the basis for decisions between tolerance and activation.
在免疫反应过程中，传递给T细胞的众多受体介导信号指导其增殖、存活和分化。在此，我们描述了一种定量模型和体外方法，用于评估T细胞处理这些多种信号时所采用的“计算方式”。该模型揭示了T细胞如何将独立接收的信号转化为对分裂时间的线性累加效应，进而使T细胞数量呈指数级增长。这些结果解释了为何如此多的配体对T细胞激活似乎都必不可少，并主张重新审视双信号理论作为耐受与激活之间决策基础的观点。
