高效抗逆转录病毒疗法（HAART）与免疫激活的循环标志物：HAART对新蝶呤的特定作用
Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: specific effect of HAART on neopterin.
作者信息
Amirayan-Chevillard N, Tissot-Dupont H, Obadia Y, Gallais H, Mege J L, Capo C
机构信息
Faculté de Médecine, Unité des Rickettsies, Université de la Méditerranée, CNRS UPRESA 6020, 13385 Marseille Cedex 5, France.
出版信息
Clin Diagn Lab Immunol. 2000 Sep;7(5):832-4. doi: 10.1128/CDLI.7.5.832-834.2000.
Abstract
The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin levels. This effect is reversible, since neopterin levels increased after the arrest of treatment. Their determination may be useful in the evaluation of the efficacy of antiretroviral therapy.
摘要
在人类免疫缺陷病毒感染患者中，包括新蝶呤、肿瘤坏死因子Ⅱ型受体和白细胞介素-2受体在内的免疫激活标志物的循环水平会升高。我们在此表明，高效抗逆转录病毒疗法可显著降低新蝶呤水平。这种效应是可逆的，因为治疗停止后新蝶呤水平会升高。对它们的测定可能有助于评估抗逆转录病毒疗法的疗效。
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