Dam Nielsen S, Kjaer Ersboll A, Mathiesen L, Nielsen J O, Hansen J E
Department of Infectious Diseases, Hvidovre Hospital, Frederiksberg, Denmark.
J Infect Dis. 1998 Nov;178(5):1299-305. doi: 10.1086/314464.
CD34 cells from human immunodeficiency virus (HIV)-infected persons have been described to be impaired in function. The effect of highly active antiretroviral treatment (HAART) on the function of CD34 cells in HIV-infected patients was examined. Numbers and function of CD34 cells from 11 HIV-infected patients were determined prior to HAART and after 2, 4, 8, and 12 weeks of therapy. The mean number of colony-forming units (cells) per milliliter (cfu/mL) was 15.0 prior to HAART vs. 109.8 in healthy controls (P<.001). During HAART, the number of cfu/mL increased to 100.3 (P<.001). This increase in cfu/mL eliminated the differences between HIV-infected patients and controls. Significant increases in numbers of CD34 cells were not detected. Of importance, the cloning efficiency of CD34 cells increased from 1.7% prior to therapy to a peak at 18.7% (P=.003). In conclusion, HAART normalized CD34 cell function in HIV-infected patients and thus might allow de novo production of T lymphocytes from progenitor cells.
据描述，来自人类免疫缺陷病毒（HIV）感染者的CD34细胞功能受损。研究了高效抗逆转录病毒治疗（HAART）对HIV感染患者CD34细胞功能的影响。在HAART治疗前以及治疗2周、4周、8周和12周后，测定了11例HIV感染患者的CD34细胞数量和功能。HAART治疗前，每毫升集落形成单位（细胞）（cfu/mL）的平均数为15.0，而健康对照为109.8（P<0.001）。在HAART治疗期间，cfu/mL增加到100.3（P<0.001）。cfu/mL的这种增加消除了HIV感染患者与对照之间的差异。未检测到CD34细胞数量的显著增加。重要的是，CD34细胞的克隆效率从治疗前的1.7%增加到峰值18.7%（P = 0.003）。总之，HAART使HIV感染患者的CD34细胞功能正常化，因此可能允许从祖细胞重新产生T淋巴细胞。
