Ferrer J M, Sabater R, Sáez J A
Department of Physiology, School of Medicine, University of Granada, Spain.
Neuroreport. 1992 Nov;3(11):1027-9. doi: 10.1097/00001756-199211000-00021.
Intracerebral microinjections of neurotensin (NT) decrease intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MPC) in the rat. This effect could be due to the ability of NT to bind dopamine. To test this hypothesis we studied the effects of intracerebral microinjections of neuromedin N, a natural NT analogue that does not bind dopamine, on ICSS of the rat MPC. Unilateral microinjections of neuromedin N into the MPC at doses of 2.5, 5, 10, 20 and 40 nmol produced a dose-related decrease in ICSS of the ipsilateral MPC. ICSS of the contralateral MPC, used as a control, was not affected by the microinjections. These results suggest that the inhibitory effect of NT on ICSS is independent of NT-dopamine binding. Because neuromedin N is also present in the MPC, these results also suggest a possible neuromodulatory role of this neuropeptide on ICSS of the prefrontal cortex.
向大鼠脑内微量注射神经降压素（NT）会降低内侧前额叶皮质（MPC）的颅内自我刺激（ICSS）。这种效应可能归因于NT与多巴胺结合的能力。为了验证这一假设，我们研究了向大鼠MPC脑内微量注射神经介素N（一种不与多巴胺结合的天然NT类似物）对ICSS的影响。以2.5、5、10、20和40 nmol的剂量将神经介素N单侧微量注射到MPC中，会使同侧MPC的ICSS呈剂量依赖性降低。作为对照的对侧MPC的ICSS不受微量注射的影响。这些结果表明，NT对ICSS的抑制作用与NT-多巴胺结合无关。由于神经介素N也存在于MPC中，这些结果还表明这种神经肽对前额叶皮质ICSS可能具有神经调节作用。
