抗生素A-16316-C，一种新型水溶性碱性抗生素。

Antibiotic A-16316-C, a new water-soluble basic antibiotic.

作者信息

Tamura A, Furuta R, Kotani H

出版信息

J Antibiot (Tokyo). 1975 Apr;28(4):260-5. doi: 10.7164/antibiotics.28.260.

DOI:10.7164/antibiotics.28.260

Abstract

A new water-soluble basic antibiotic named antibiotic A-16316-C was isolated together with antibiotic A-396-I and hygromycin B from a streptomyces strain identified as Streptoverticullium eurocidicus. The properties of the antibiotic A-16316-C were similar to those of destomycin B. But it was found that the antibiotic A-16316-C was not identical with destomycin B on the basis of NMR analysis. On acidic degradation antibiotic A-16136-C gave N, N'-dimethyl-2-deoxystreptamine, destomic acid and D-mannose. The gross structure for antibiotic A-16136-C was deduced from chemical reactions and spectral data.

摘要

从一株鉴定为欧洲链霉菌的链霉菌菌株中，分离出一种名为抗生素A-16316-C的新型水溶性碱性抗生素，同时还分离出了抗生素A-396-I和潮霉素B。抗生素A-16316-C的性质与去氧土霉素B相似。但基于核磁共振分析发现，抗生素A-16316-C与去氧土霉素B并不相同。在酸性降解条件下，抗生素A-16136-C产生N，N'-二甲基-2-脱氧链霉胺、去氧土霉素酸和D-甘露糖。通过化学反应和光谱数据推断出了抗生素A-16136-C的总体结构。