El-Gendy Mervat M A, Shaaban Mohamed, Shaaban Khaled A, El-Bondkly Ahmed M, Laatsch Hartmut
Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries, National Research Centre, Dokki-Cairo, Egypt.
J Antibiot (Tokyo). 2008 Mar;61(3):149-57. doi: 10.1038/ja.2008.124.
In the course of our screening program for new bio-active compounds, a novel triazolopyrimidine antibiotic, essramycin (1), was obtained from the culture broth of the marine Streptomyces sp., isolate Merv8102. Structure 1 was established by intensive NMR studies and by mass spectra. The compound is antibacterially active with MIC of 2 to 8 microg/ml against Gram-positive and Gram-negative bacteria, while it showed no antifungal activity. The fermentation and isolation, as well as the structure elucidation and biological activity of 1 are described.
在我们对新型生物活性化合物的筛选过程中，从海洋链霉菌属菌株Merv8102的培养液中获得了一种新型三唑并嘧啶抗生素——埃斯拉霉素（1）。通过深入的核磁共振研究和质谱确定了化合物1的结构。该化合物具有抗菌活性，对革兰氏阳性菌和革兰氏阴性菌的最低抑菌浓度为2至8微克/毫升，而未显示出抗真菌活性。本文描述了化合物1的发酵、分离以及结构解析和生物活性。
