Wyszogrodski I, Kyei-Aboagye K, Taeusch H W, Avery M E
J Appl Physiol. 1975 Mar;38(3):461-6. doi: 10.1152/jappl.1975.38.3.461.
Hyperventilation, defined as repeated hyperinflations, for three hours in open-chested anesthetized cats increased elastic recoil and elevated minimum surface tension of lung extracts as measured on a surface film balance. Equivalent hyperventilation from an elevated lung volume did not alter the pressure-volume relationships. When a mixture of [3H]glycerol and [14C]palmitate had been injected 17 h before the three hour period of phyerventilation, an increase in the ratio of specific activity in wash to tissue lecithin occurred in the hyperventilated cats compared to controls. These findings suggest that hyperventilation promotes release of surface active material from tissue to alveolus, but the released material is inactivated. The application of 2.5 cmH2O positive end-expiratory pressure prevented the adverse effects of hyperventilation. The same increase in wash to tissue lecithin occurred during this study; since the material was appropriately surface active, we conclude that the positive end-expiratory pressure prevented its inactivation.
通气过度定义为反复过度充气，在开胸麻醉的猫中持续三小时的通气过度会增加弹性回缩力，并提高用表面膜天平测量的肺提取物的最小表面张力。从升高的肺容积进行等效通气过度不会改变压力-容积关系。当在三小时通气过度期前17小时注射[3H]甘油和[14C]棕榈酸的混合物时，与对照组相比，通气过度的猫中冲洗液与组织卵磷脂的比活性增加。这些发现表明通气过度促进表面活性物质从组织释放到肺泡，但释放的物质失活。施加2.5 cmH2O的呼气末正压可预防通气过度的不良影响。在本研究期间冲洗液与组织卵磷脂也出现了相同的增加；由于该物质具有适当的表面活性，我们得出结论，呼气末正压可防止其失活。
