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Gelatinase B deficiency impairs reproduction.明胶酶B缺乏会损害生殖功能。
J Clin Invest. 2000 Sep;106(5):627-8. doi: 10.1172/JCI10910.
2
Gelatinase B deficiency protects against endotoxin shock.明胶酶B缺乏可预防内毒素休克。
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In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes.急性胰腺炎中胰蛋白酶对明胶酶B/基质金属蛋白酶-9的体内激活是链脲佐菌素诱导糖尿病的一个促成因素。
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Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.明胶酶B（基质金属蛋白酶-9）缺陷小鼠早期血管通透性增强：巨噬细胞来源的COX-1衍生PGE2的假定作用
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Letter by Pinto and Heymans regarding article, "Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice".
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Metalloproteases and their inhibitors in the postpartum endometrial remodeling in dairy cows: their relationship with days to conception after parturition.奶牛产后子宫内膜重塑中的金属蛋白酶及其抑制剂：它们与产后受孕天数的关系。
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Mmp2 Deficiency Leads to Defective Parturition and High Dystocia Rates in Mice.Mmp2 缺乏导致小鼠分娩缺陷和难产率升高。
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Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma.血清基质金属蛋白酶-13 作为皮肤鳞状细胞癌的诊断生物标志物。
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Matrix metalloproteinases 2 and 9 are elevated in human preterm laboring uterine myometrium and exacerbate uterine contractility†.基质金属蛋白酶 2 和 9 在人类早产临产的子宫平滑肌中升高，并加重子宫收缩力。
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Propeptide glycosylation and galectin-3 binding decrease proteolytic activation of human proMMP-9/progelatinase B.前肽糖基化和半乳糖凝集素-3 结合降低了人 proMMP-9/明胶酶 B 的蛋白水解激活。
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9
Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis.明胶酶 B/基质金属蛋白酶-9 是实验性自身免疫性脑脊髓炎中一种与 Fas 无关的、具有时相特异性的效应分子。
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Impact of MMP-2 and MMP-9 enzyme activity on wound healing, tumor growth and RACPP cleavage.基质金属蛋白酶-2 和基质金属蛋白酶-9 酶活性对伤口愈合、肿瘤生长和 RACPP 裂解的影响。
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本文引用的文献

1
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.基质金属蛋白酶-9（明胶酶B）的靶向基因破坏抑制实验性腹主动脉瘤的发展。
J Clin Invest. 2000 Jun;105(11):1641-9. doi: 10.1172/JCI8931.
2
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.年轻的明胶酶B缺陷小鼠对实验性自身免疫性脑脊髓炎和坏死性尾部病变的抵抗力。
J Clin Invest. 1999 Dec;104(11):1507-15. doi: 10.1172/JCI6886.
3
Matrix metalloproteinase-9/gelatinase B is required for process outgrowth by oligodendrocytes.少突胶质细胞的突起生长需要基质金属蛋白酶-9/明胶酶B。
J Neurosci. 1999 Oct 1;19(19):8464-75. doi: 10.1523/JNEUROSCI.19-19-08464.1999.
4
Experimental metastasis is suppressed in MMP-9-deficient mice.在基质金属蛋白酶-9缺陷型小鼠中，实验性转移受到抑制。
Clin Exp Metastasis. 1999 Mar;17(2):177-81. doi: 10.1023/a:1006603723759.
5
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.基质金属蛋白酶缺乏会影响接触性超敏反应：基质溶解素-1缺乏会阻止该反应，而明胶酶B缺乏会延长该反应。
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6885-9. doi: 10.1073/pnas.96.12.6885.
6
Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid.明胶酶B缺陷小鼠对实验性大疱性类天疱疮具有抗性。
J Exp Med. 1998 Aug 3;188(3):475-82. doi: 10.1084/jem.188.3.475.
7
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.基质金属蛋白酶-9/明胶酶B是生长板血管生成和肥大软骨细胞凋亡的关键调节因子。
Cell. 1998 May 1;93(3):411-22. doi: 10.1016/s0092-8674(00)81169-1.
8
Immunolocalization of the matrix metalloproteinases gelatinase B and stromelysin 1 in human endometrium throughout the menstrual cycle.
J Reprod Fertil. 1996 May;107(1):43-51. doi: 10.1530/jrf.0.1070043.
9
Developmental expression of MMP-9 (gelatinase B) mRNA in mouse embryos.基质金属蛋白酶-9（明胶酶B）mRNA在小鼠胚胎中的发育表达。
Dev Dyn. 1995 Sep;204(1):30-40. doi: 10.1002/aja.1002040105.
10
92-kd type IV collagenase (matrix metalloproteinase-9) activity in human amniochorion increases with labor.人羊膜绒毛膜中92-kd IV型胶原酶（基质金属蛋白酶-9）的活性随分娩而增加。
Am J Pathol. 1995 Jan;146(1):148-56.

Gelatinase B deficiency impairs reproduction.

作者信息

Dubois B, Arnold B, Opdenakker G

出版信息

J Clin Invest. 2000 Sep;106(5):627-8. doi: 10.1172/JCI10910.

DOI:10.1172/JCI10910
PMID:10974013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC381291/
Abstract
摘要