Kiss J P
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
Brain Res Bull. 2000 Aug;52(6):459-66. doi: 10.1016/s0361-9230(00)00282-3.
Data accumulated in the last decade indicate that nitric oxide (NO) participates in the regulation of neurotransmission in the central nervous system. Due to its physicochemical properties, NO is an ideal mediator of nonsynaptic interactions. The importance of monoaminergic systems in the function of the brain is clearly shown by the number of severe neuropsychiatric diseases (e.g. depression, Parkinson's disease) caused by the impairment of monoaminergic neurotransmission. Because of their neuroanatomical characteristic, monoaminergic systems participate mainly in nonsynaptic interactions. Since NO is a potential nonsynaptic modulator, it may have an important role in the regulation of monoaminergic systems. The aim of the present review is to survey the literature on the effect of NO on dopaminergic, noradrenergic and serotonergic neurotransmission. The potential mechanisms of action are summarized. Since there is no agreement in the literature on the nature of the effect of NO exerted on monoaminergic neurotransmission, and there are contradictory data concerning the mechanisms involved, the possible reasons for this unusual inconsistency are also discussed.
过去十年积累的数据表明，一氧化氮（NO）参与中枢神经系统神经传递的调节。由于其物理化学性质，NO是非突触相互作用的理想介质。单胺能系统在大脑功能中的重要性通过单胺能神经传递受损导致的严重神经精神疾病（如抑郁症、帕金森病）的数量得到了清楚的体现。由于其神经解剖学特征，单胺能系统主要参与非突触相互作用。由于NO是一种潜在的非突触调节剂，它可能在单胺能系统的调节中发挥重要作用。本综述的目的是综述有关NO对多巴胺能、去甲肾上腺素能和5-羟色胺能神经传递影响的文献。总结了潜在的作用机制。由于文献中对于NO对单胺能神经传递作用的性质没有达成共识，并且关于所涉及的机制存在相互矛盾的数据，因此还讨论了这种异常不一致的可能原因。
