Pietruszewska W, Niewiadomska H, Kobos J, Józefowicz-Korczyńska M, Gryczyński M
Katedra i Klinika Otolaryngologii AM w Lodzi.
Otolaryngol Pol. 2000;54 Suppl 31:167-70.
Angiogenesis as multistage process, which is required for forming of new vessels and is essential for the growth of solid tumors and making metastasis. Sixty patients with laryngeal cancer were analyzed. They were treated in ENT Department of Medical University in Lodz and follow-up period was not shorter than 5 years. Intensity of neovascularisation was examined by means of immunohistochemical techniques carried out on paraffin sections using selected antibody against antigens of vessel cells. The value of the prognostic factors of angiogenesis intensity were evaluated against: dissected nodal metastasis, tumor recurrences and metastasis observed in prospective follow-up and after cancer treatment live time. Morphological properities of tumor or hospital treatment of the patients with laryngeal cancer were analyzed as well. Taking into consideration the results, we can make the conclusion that investigation of angiogenesis can be forthcoming prognostic factor for the laryngeal cancer.
血管生成是一个多阶段过程，是形成新血管所必需的，对实体瘤的生长和转移至关重要。对60例喉癌患者进行了分析。他们在罗兹医科大学耳鼻喉科接受治疗，随访期不少于5年。通过免疫组织化学技术在石蜡切片上使用针对血管细胞抗原的选定抗体来检测新血管形成的强度。根据以下指标评估血管生成强度的预后因素值：解剖的淋巴结转移、肿瘤复发以及在前瞻性随访和癌症治疗后的生存时间中观察到的转移。还分析了喉癌患者的肿瘤形态学特征或住院治疗情况。考虑到结果，我们可以得出结论，血管生成研究可能成为喉癌的一个有前景的预后因素。
