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[餐后血糖峰值对糖化血红蛋白及血管病变的特定影响]

[Specific effect of postprandial glycemic peaks on HBA1c and angiopathy].

作者信息

Avignon A, Monnier L

出版信息

Diabetes Metab. 2000 Jun;26 Suppl 2:12-5.

Abstract

Most studies argue for a strong relation between postprandial blood glucose and cardiovascular risk. Thus the DIS study establishes a significant link between postprandial glucose and the incidence of myocardial infarction as well as the occurrence of death. The DECODE study shows that identifying individuals at risk for death can be done through OGTT 2 h blood glucose, whatever fasting glycemia is. Kumamoto study shows a reduction in microangiopathic complications when postprandial blood glucose is corrected by a multiinjection protocol. Finally, a study conducted in Montpellier shows that postprandial blood glucose better reflects the overall diabetes control than fasting glycemia. Altogether, these data suggest that managing postprandial blood glucose is essential for the prevention of vascular outcome in diabetic patients.

摘要

大多数研究认为餐后血糖与心血管风险之间存在密切关系。因此,糖尿病干预和并发症研究(DIS)证实了餐后血糖与心肌梗死发生率以及死亡发生之间存在显著联系。糖尿病流行病学协作分析组(DECODE)研究表明,无论空腹血糖水平如何,通过口服葡萄糖耐量试验(OGTT)2小时血糖水平都可以识别出有死亡风险的个体。熊本研究表明,采用多次注射方案纠正餐后血糖后,微血管并发症会减少。最后,在蒙彼利埃进行的一项研究表明,与空腹血糖相比,餐后血糖能更好地反映糖尿病的总体控制情况。总之,这些数据表明,控制餐后血糖对于预防糖尿病患者的血管病变至关重要。

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