中药配方冰得灵可刺激小鼠产生多方面的免疫反应。

Bing de ling, a Chinese herbal formula, stimulates multifaceted immunologic responses in mice.

作者信息

Niu G, Tan J, Turner J G, Brabham J G, Burdelya L G, Crucian B E, Wall-Apelt H, Zhao R J, Yu H

机构信息

Immunology Program, H. Lee Moffitt Cancer Center & Research Institute, Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, USA.

出版信息

DNA Cell Biol. 2000 Aug;19(8):515-20. doi: 10.1089/10445490050128449.

DOI:10.1089/10445490050128449

PMID:10975469

Abstract

Bing de ling is a Chinese herbal formula most commonly used in complementary medical settings against viral disorders. We have found that bing de ling potentiates upregulation of immune activity when administered to mice in dosages proportional to those used clinically. These mice demonstrated significant elevation of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in splenocytes and enhancement of macrophage, natural killer cell, and lymphokine-activated killer cell cytotoxicity. These data are consistent with bing de ling's clinically observed efficacy against viruses and identify the formula as a promising candidate for clinical trials against diverse diseases that may respond to increased immunologic activity.

摘要

冰得灵是一种中药配方，在辅助医疗环境中最常用于对抗病毒疾病。我们发现，当以与临床使用剂量成比例的剂量给小鼠施用时，冰得灵可增强免疫活性的上调。这些小鼠的脾细胞中白细胞介素-2（IL-2）和干扰素-γ（IFN-γ）的产生显著增加，巨噬细胞、自然杀伤细胞和淋巴因子激活的杀伤细胞的细胞毒性增强。这些数据与冰得灵在临床上观察到的抗病毒疗效一致，并确定该配方是针对可能对免疫活性增加有反应的多种疾病进行临床试验的有希望的候选者。