Lancefield R C, McCarty M, Everly W N
J Exp Med. 1975 Jul 1;142(1):165-79. doi: 10.1084/jem.142.1.165.
The data presented in this paper establish the finding that multiple specific protective antibodies exist in rabbits in response to immunization with Group B streptococci. The summary in Table I indicates the serological types into which Group B streptococci have been divided on the basis of their antigenic composition. This classification is dependent upon passive protection of mice with antibodies directed against the specific antigens, and types are defined in these terms. Heretofore, it was thought that type-specific polysaccharides accounted for all such protection in Group B streptococci. Certain exceptions of cross-protection between types due to minor polysaccharide determinants soon appeared; cross-protection reactions based on protein determinants in at least two types were also discovered. The present experiments show that specific antibodies directed to either polysaccharide or protein antigens of a single strain can be protective against infection with streptococci containing these antigens.
家兔在接种B族链球菌后会产生多种特异性保护性抗体。表I中的总结表明了B族链球菌根据其抗原组成所划分的血清型。这种分类依赖于用针对特定抗原的抗体对小鼠进行被动保护，并据此定义血清型。在此之前，人们认为B族链球菌中所有此类保护作用均由型特异性多糖引起。由于次要多糖决定簇，不同血清型之间很快就出现了某些交叉保护的例外情况；还发现了至少两种血清型中基于蛋白质决定簇的交叉保护反应。目前的实验表明，针对单一菌株的多糖或蛋白质抗原的特异性抗体可保护机体免受含有这些抗原的链球菌感染。
