Takeda T, Momose A, Yu Q, Yuasa T, Dilmanian F A, Akatsuka T, Itai Y
Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Cell Mol Biol (Noisy-le-grand). 2000 Sep;46(6):1077-88.
New types of X-ray computed tomography (CT), fluorescent X-ray CT and phase-contrast X-ray CT are being developed for biomedical research. While fluorescent scanning X-ray CT (FXCT) can detect specific contrast elements, or endogenous iodine, at very low content (less than 400 pg iodine of tissue in a volume of 8 x 10(-6) ml), the phase-contrast X-ray CT (PCCT) is a highly sensitive imaging technique to differentiate between different biological tissue types (based on their specific gravity variation) without the use of a contrast agent. Therefore, we can expect functional diagnosis with FXCT, and high contrast, high resolution biological imaging with PCCT. In this paper, a human thyroid gland imaged by FXCT, and a metastatic human cancerous lesion depicted using PCCT are presented. The latter method used a newly manufactured, large, monolithic, X-ray interferometer, which is described in this paper in detail.
新型的X射线计算机断层扫描（CT）、荧光X射线CT和相衬X射线CT正在为生物医学研究而开发。虽然荧光扫描X射线CT（FXCT）能够检测含量极低（在8×10⁻⁶毫升的组织中碘含量低于400皮克碘）的特定对比元素或内源性碘，但相衬X射线CT（PCCT）是一种无需使用造影剂就能根据不同生物组织类型的比重差异来区分它们的高灵敏度成像技术。因此，我们可以期待用FXCT进行功能诊断，并用PCCT进行高对比度、高分辨率的生物成像。本文展示了通过FXCT成像的人体甲状腺以及使用PCCT描绘的转移性人类癌性病变。后一种方法使用了一种新制造的大型整体式X射线干涉仪，本文将对此进行详细描述。
