喹喔啉研究。23. 潜在抗疟药。取代的5,8-二甲氧基喹喔啉。
Quinoxaline studies. 23. Potential antimalarials. Substituted 5,8-dimethoxyquinoxalines.
作者信息
Fisher G H, Moreno H R, Oatis J E, Schultz H P
出版信息
J Med Chem. 1975 Jul;18(7):746-52. doi: 10.1021/jm00241a021.
Two series of 2,3-disubstituted 5,8-dimethoxy-6-[N- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents H, CH3, C6H5, C6H4-4-Cl, and CH2C6H5; and the second with identical styryl groups CH=CHC6H5, CH=CHC6H4-4-Cl, CH=CHC6H3-3,4-C12, CH=CHC6H4-4-F, CH=CHC6H4-4-CF3, and CH=CHC6H4-4-NO2. None of the substances possessed antimalarial activity; several were toxic at highest dosage levels.
制备了两个系列的2,3-二取代5,8-二甲氧基-6-[N-(ω-二甲基氨基烷基)氨基]喹喔啉：第一个系列具有相同的2,3-取代基H、CH₃、C₆H₅、C₆H₄-4-Cl和CH₂C₆H₅；第二个系列具有相同的苯乙烯基CH=CHC₆H₅、CH=CHC₆H₄-4-Cl、CH=CHC₆H₃-3,4-C1₂、CH=CHC₆H₄-4-F、CH=CHC₆H₄-4-CF₃和CH=CHC₆H₄-4-NO₂。这些物质均无抗疟活性；有几种在最高剂量水平时具有毒性。
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