Quinoxaline studies. 23. Potential antimalarials. Substituted 5,8-dimethoxyquinoxalines.
作者信息
Fisher G H, Moreno H R, Oatis J E, Schultz H P
出版信息
J Med Chem. 1975 Jul;18(7):746-52. doi: 10.1021/jm00241a021.
PMID:1097693
Abstract
Two series of 2,3-disubstituted 5,8-dimethoxy-6-[N- (omega-dimethylaminoalkyl) amino] quinoxalines were prepared: the first series with identical 2,3-substituents H, CH3, C6H5, C6H4-4-Cl, and CH2C6H5; and the second with identical styryl groups CH=CHC6H5, CH=CHC6H4-4-Cl, CH=CHC6H3-3,4-C12, CH=CHC6H4-4-F, CH=CHC6H4-4-CF3, and CH=CHC6H4-4-NO2. None of the substances possessed antimalarial activity; several were toxic at highest dosage levels.
摘要
Zotero 插件