二苯并[c,e]氮杂䓬衍生物的合成及其抗疟活性
Synthesis and antimalarial activity of dibenz[c, e]azepine derivatives.
作者信息
Warner A M, Neumeyer J L
出版信息
J Pharm Sci. 1976 Jun;65(6):928-9. doi: 10.1002/jps.2600650636.
PMID:778378
Abstract
A series of 6-alkyl-2,10-bis(trifluoromethyl)-5H-dibenz-[c,e]azepines were synthesized via a condensation reaction between 5,5'-bis(trifluoromethyl)-2,2'-diformylbiphenyl and the appropriate amine. These compounds were screened for antimalarial activity and were found to be inactive.
摘要
通过5,5'-双（三氟甲基）-2,2'-二甲酰基联苯与适当的胺之间的缩合反应合成了一系列6-烷基-2,10-双（三氟甲基）-5H-二苯并[c,e]氮杂䓬。对这些化合物进行了抗疟活性筛选，发现它们没有活性。
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