Matsumoto H, Niimi A, Satou S, Kishi K
Department of Respiratory Medicine, Kyoto University.
Nihon Kokyuki Gakkai Zasshi. 2000 Jun;38(6):461-5.
We reported a case of chronic cough due to gastroesophageal reflux (GER). The patient was a 29-year-old woman who had suffered from persistent chronic cough for more than 3 years. She had been treated with high doses of inhaled steroids, oral bronchodilators, and oral corticosteroids on a presumed diagnosis of asthma. However, her cough was not alleviated by these treatments, and the patient was referred to our hospital. She did not exhibit typical GER symptoms except for belch. Although esophagoscopy did not disclose reflux esophagitis, esophageal pH monitoring revealed acid reflux 7 to 8 times higher than the reference value. The patient was treated with a proton-pump inhibitor, which markedly alleviated her cough. Chronic cough due to GER was diagnosed. Although the incidence of chronic cough due to GER was thought to be rare in Japan, the findings in our case report underscored the importance of this association to the differential diagnosis of chronic cough.
我们报告了一例因胃食管反流（GER）引起的慢性咳嗽病例。患者为一名29岁女性，持续慢性咳嗽超过3年。她曾因疑似哮喘接受高剂量吸入性类固醇、口服支气管扩张剂和口服皮质类固醇治疗。然而，这些治疗并未缓解她的咳嗽，患者遂转诊至我院。除嗳气外，她未表现出典型的GER症状。尽管食管镜检查未发现反流性食管炎，但食管pH监测显示酸反流比参考值高7至8倍。患者接受质子泵抑制剂治疗后，咳嗽明显缓解。诊断为GER引起的慢性咳嗽。尽管在日本，GER引起的慢性咳嗽发病率被认为较低，但我们病例报告中的发现强调了这种关联在慢性咳嗽鉴别诊断中的重要性。
