Mainie I, Tutuian R, Agrawal A, Hila A, Highland K B, Adams D B, Castell D O
Division of Gastroenterology and Hepatology, Medical University South Carolina, 96 Jonathan Lucas Street, 210 Clinical Science Building, P O Box 250327 Charleston, SC 29425, USA.
Thorax. 2005 Jun;60(6):521-3. doi: 10.1136/thx.2005.040139.
The symptoms of extra-oesophageal gastro-oesophageal reflux disease (GORD) (such as chronic cough and hoarseness) are traditionally more difficult to treat than typical GORD symptoms (heartburn and regurgitation). Patients with extra-oesophageal manifestations may require longer and higher doses of acid suppressive therapy. In patients not responding to acid suppressive therapy the physician faces a dilemma as to whether the symptoms are due to ongoing acid reflux, non-acid reflux, or not associated with reflux. We report the case of a 45 year old woman with a history of a chronic cough referred for fundoplication after documenting her symptoms were associated with non-acid reflux using multichannel intraluminal impedance and pH (MII-pH).
食管外胃食管反流病（GORD）的症状（如慢性咳嗽和声音嘶哑）传统上比典型的GORD症状（烧心和反流）更难治疗。有食管外表现的患者可能需要更长时间、更高剂量的抑酸治疗。对于抑酸治疗无反应的患者，医生面临一个两难境地，即症状是由于持续的酸反流、非酸反流还是与反流无关。我们报告了一例45岁有慢性咳嗽病史的女性病例，在通过多通道腔内阻抗和pH值（MII-pH）记录到其症状与非酸反流相关后，转诊进行胃底折叠术。
