Kharchenko N K
Ukrainian Scientific-Research Institute of Social and Forensic Psychiatry, Ministry of Public Health of Ukraine, Kyiv.
Ukr Biokhim Zh (1999). 2000 Jan-Feb;72(1):75-81.
Aldehyde dehydrogenase activity (KF 1.2.1.3) of cytosol fractions of brain structures (hypothalamus, midbrain and new cortex) as well as dophamine content in these structures were studied in comparative aspect in rats preferring and rejection ethanol. It has been shown that there were two isoforms of aldehyde dehydrogenases (aldehyde dehydrogenase 1 and aldehyde dehydrogenase 2) in cytosol fractions of all investigated brain structures of animals preferring ethanol while only aldehyde dehydrogenase 2 has been found in the new cotex of rats rejecting ethanol. Thus, aldehyde-dehydrogenase activity is higher in the animals preferring ethanol than in those ones rejecting ethanol. Content of dophamine in the rats preferring ethanol is higher than in those ones rejecting ethanol both in the hypothalamus and new cortex. Differences between the studied groups of animals can underlie the pathologic attraction to alcohol.
对偏好和拒斥乙醇的大鼠大脑结构（下丘脑、中脑和新皮层）胞质溶胶部分的乙醛脱氢酶活性（KF 1.2.1.3）以及这些结构中的多巴胺含量进行了比较研究。结果表明，偏好乙醇的动物所有被研究大脑结构的胞质溶胶部分存在两种乙醛脱氢酶同工型（乙醛脱氢酶1和乙醛脱氢酶2），而在拒斥乙醇的大鼠新皮层中仅发现了乙醛脱氢酶2。因此，偏好乙醇的动物中乙醛脱氢酶活性高于拒斥乙醇的动物。偏好乙醇的大鼠下丘脑和新皮层中的多巴胺含量均高于拒斥乙醇的大鼠。所研究的动物组之间的差异可能是对酒精产生病理性吸引力的基础。
