Zimatkin S M, Lis L E
Farmakol Toksikol. 1988 Nov-Dec;51(6):92-4.
One hour after intraperitoneal administration of ethanol at a dose of 3.5 g/kg the activity of aldehyde dehydrogenase (EC 1.2.1.3) decreased in n. accumbens capillaries of the cerebral cortex and cerebellum and in neurocytes of the sensomotor cortex. This indicates a transient weakening of aldehyde-metabolizing activity, particularly in the region of the cerebral neocortex. Six hours later the activity of the enzyme in most brain structures was increased, which is the manifestation of neurochemical adaptation to the elevated level of aldehydes.
腹腔注射剂量为3.5 g/kg的乙醇1小时后，大脑皮层、小脑伏隔核毛细血管以及感觉运动皮层神经细胞中的醛脱氢酶（EC 1.2.1.3）活性降低。这表明醛代谢活性出现短暂减弱，尤其是在大脑新皮层区域。6小时后，大多数脑结构中的该酶活性增加，这是对醛水平升高的神经化学适应性表现。
