Van Gestel S, Houwing-Duistermaat J J, Adolfsson R, van Duijn C M, Van Broeckhoven C
Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Department of Biochemistry, Belgium.
Behav Genet. 2000 Mar;30(2):141-6. doi: 10.1023/a:1001907321955.
A power calculation is described in which the power of selective genotyping in genetic association studies of quantitative traits is evaluated. The method of selective genotyping implies the selection of the extremely high and low scoring individuals from the continuous distribution of a quantitative trait. The selected individuals are genotyped and association is tested. In the power calculation the following parameters are varied: total sample size of the phenotyped group (1000, 1500, 2000); selection of extremely high and low scoring individuals (2.5%, 5%, 10%); allele frequency of the risk increasing allele (0.10 to 0.90); mode of inheritance and proportion of variance explained by the quantitative trait locus (QTL) (omega 2 = 0.01, 0.05, 0.10). We conclude that the method of selective genotyping is a powerful method to detect association for a quantitative trait.
本文描述了一种功效计算方法，用于评估数量性状遗传关联研究中选择性基因分型的功效。选择性基因分型方法意味着从数量性状的连续分布中选择得分极高和极低的个体。对所选个体进行基因分型并测试关联性。在功效计算中，以下参数会发生变化：表型组的总样本量（1000、1500、2000）；得分极高和极低个体的选择比例（2.5%、5%、10%）；风险增加等位基因的频率（0.10至0.90）；遗传模式以及数量性状基因座（QTL）解释的方差比例（ω2 = 0.01、0.05、0.10）。我们得出结论，选择性基因分型方法是检测数量性状关联性的一种有效方法。
