Scholes D, Hooton T M, Roberts P L, Stapleton A E, Gupta K, Stamm W E
Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA 98101.
J Infect Dis. 2000 Oct;182(4):1177-82. doi: 10.1086/315827. Epub 2000 Aug 31.
To define host factors associated with an increased risk of recurrent urinary tract infection (RUTI), a case-control study was conducted in 2 populations: university women and health maintenance organization enrollees. Case patients were 229 women 18-30 years old with RUTIs; control subjects were 253 randomly selected women with no RUTI history. In a multivariate model, independent risk factors for RUTI included recent 1-month intercourse frequency (odds ratio [OR], 5.8; 95% confidence interval [CI], 3.1-10.6 for 4-8 episodes), 12-month spermicide use (OR, 1.8; 95% CI, 1.1-2.9), and new sex partner during the past year (OR, 1.9; 95% CI, 1.2-3.2). Two newly identified risk factors were age at first urinary tract infection (UTI) </=15 years (OR, 3.9; 95% CI, 1.9-8.0) and UTI history in the mother (OR, 2.3; 95% CI, 1.5-3.7). Blood group and secretor phenotype were not associated with RUTI. In young women, risk factors for sporadic UTI are also risk factors for recurrence. Two predictors suggest that genetic/long-term environmental exposures also predispose to RUTI.
为了确定与复发性尿路感染（RUTI）风险增加相关的宿主因素，在两个人群中进行了一项病例对照研究：大学女性和健康维护组织的参保者。病例患者为229名年龄在18至30岁之间的复发性尿路感染女性；对照对象为253名随机选择的无复发性尿路感染病史的女性。在多变量模型中，复发性尿路感染的独立危险因素包括最近1个月的性交频率（比值比[OR]为5.8；95%置信区间[CI]为4至8次性交时为3.1至10.6）、12个月内使用杀精剂（OR为1.8；95%CI为1.1至2.9）以及过去一年中有新的性伴侣（OR为1.9；95%CI为1.2至3.2）。两个新发现的危险因素是首次尿路感染（UTI）年龄≤15岁（OR为3.9；95%CI为1.9至8.0）和母亲有尿路感染病史（OR为2.3；95%CI为1.5至3.7）。血型和分泌型表型与复发性尿路感染无关。在年轻女性中，散发性尿路感染的危险因素也是复发的危险因素。两个预测因素表明，遗传/长期环境暴露也易导致复发性尿路感染。
