Fowler V G, McIntyre L M, Yeaman M R, Peterson G E, Barth Reller L, Corey G R, Wray D, Bayer A S
Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.
J Infect Dis. 2000 Oct;182(4):1251-4. doi: 10.1086/315812. Epub 2000 Sep 8.
Platelet microbicidal proteins (PMPs) are small antimicrobial peptides secreted by mammalian platelets. In vitro resistance of Staphylococcus aureus strains to PMPs correlates with more extensive disease in experimental infective endocarditis (IE). To determine whether this same relationship exists in human S. aureus IE, we evaluated the in vitro PMP susceptibility phenotype of isolates from 58 prospectively-identified patients with definite S. aureus IE. On multivariate analyses, patients with S. aureus IE complicating an infected intravascular device were significantly more likely to have IE caused by a PMP-resistant strain (P=.0193). No correlations were detected between in vitro PMP resistance among S. aureus strains and the severity of human IE. This work supports the concept that in vitro PMP resistance in clinical S. aureus strains is associated with important clinical characteristics of S. aureus endovascular infections in vivo.
血小板杀菌蛋白（PMPs）是哺乳动物血小板分泌的小抗菌肽。金黄色葡萄球菌菌株对PMPs的体外耐药性与实验性感染性心内膜炎（IE）中更广泛的疾病相关。为了确定这种相同的关系是否存在于人类金黄色葡萄球菌IE中，我们评估了58例前瞻性确诊的金黄色葡萄球菌IE患者分离株的体外PMP敏感性表型。多变量分析显示，金黄色葡萄球菌IE合并感染性血管内装置的患者更有可能感染PMP耐药菌株（P = 0.0193）。未检测到金黄色葡萄球菌菌株的体外PMP耐药性与人类IE严重程度之间的相关性。这项研究支持了这样的概念，即临床金黄色葡萄球菌菌株的体外PMP耐药性与体内金黄色葡萄球菌血管内感染的重要临床特征相关。
