细胞大小的遗传控制。

Genetic control of cell size.

作者信息

Stocker H, Hafen E

机构信息

Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.

出版信息

Curr Opin Genet Dev. 2000 Oct;10(5):529-35. doi: 10.1016/s0959-437x(00)00123-4.

DOI:10.1016/s0959-437x(00)00123-4

PMID:10980431

Abstract

Over the past 25 years, the genetic control of cell size has mainly been addressed in yeast, a single-celled organism. Recent insights from Drosophila have shed light on the signalling pathways responsible for adjusting and maintaining cell size in metazoans. Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size.

摘要

在过去25年里，细胞大小的遗传控制主要是在单细胞生物酵母中进行研究的。果蝇研究的最新成果揭示了后生动物中负责调节和维持细胞大小的信号通路。越来越多的证据表明，存在一种在进化中保守的信号级联反应，它将外部营养源与细胞大小联系起来。