PTEN肿瘤抑制蛋白：磷脂酰肌醇3激酶信号传导的拮抗剂。 - Suppr

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

作者信息

Vazquez F, Sellers W R

机构信息

Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. doi: 10.1016/s0304-419x(99)00032-3.

DOI:10.1016/s0304-419x(99)00032-3

PMID:10656987

Abstract

摘要

相似文献

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. doi: 10.1016/s0304-419x(99)00032-3.

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4240-5. doi: 10.1073/pnas.96.8.4240.

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5. doi: 10.1073/pnas.96.5.2110.

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

J Biol Chem. 2003 Oct 10;278(41):40057-66. doi: 10.1074/jbc.M303621200. Epub 2003 Jul 17.

A surprising function for the PTEN tumor suppressor.

Science. 1998 Nov 6;282(5391):1027,1029-30. doi: 10.1126/science.282.5391.1027.

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

Curr Biol. 1998 Oct 22;8(21):1195-8. doi: 10.1016/s0960-9822(07)00493-9.

[PTEN expression in endometrial cancer and the prognosis].

Nihon Rinsho. 2004 Oct;62 Suppl 10:406-9.

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15406-11. doi: 10.1073/pnas.95.26.15406.

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

Oncogene. 1999 Dec 9;18(52):7462-8. doi: 10.1038/sj.onc.1203151.

The Cold Spring Harbor Laboratory meeting on tyrosine phosphorylation and cell signaling. Cold Spring Harbor, NY, USA, May 12-16, 1999.

Biochim Biophys Acta. 2000 Feb 14;1470(1):R17-20. doi: 10.1016/s0304-419x(99)00035-9.

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The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

作者信息

Vazquez F, Sellers W R

机构信息

Department of Adult Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. doi: 10.1016/s0304-419x(99)00032-3.

DOI:10.1016/s0304-419x(99)00032-3

PMID:10656987

Abstract

摘要

相似文献

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. doi: 10.1016/s0304-419x(99)00032-3.

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4240-5. doi: 10.1073/pnas.96.8.4240.

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5. doi: 10.1073/pnas.96.5.2110.

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

J Biol Chem. 2003 Oct 10;278(41):40057-66. doi: 10.1074/jbc.M303621200. Epub 2003 Jul 17.

A surprising function for the PTEN tumor suppressor.

Science. 1998 Nov 6;282(5391):1027,1029-30. doi: 10.1126/science.282.5391.1027.

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

Curr Biol. 1998 Oct 22;8(21):1195-8. doi: 10.1016/s0960-9822(07)00493-9.

[PTEN expression in endometrial cancer and the prognosis].

Nihon Rinsho. 2004 Oct;62 Suppl 10:406-9.

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15406-11. doi: 10.1073/pnas.95.26.15406.

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

Oncogene. 1999 Dec 9;18(52):7462-8. doi: 10.1038/sj.onc.1203151.

The Cold Spring Harbor Laboratory meeting on tyrosine phosphorylation and cell signaling. Cold Spring Harbor, NY, USA, May 12-16, 1999.

Biochim Biophys Acta. 2000 Feb 14;1470(1):R17-20. doi: 10.1016/s0304-419x(99)00035-9.

引用本文的文献

Inhibition of Rho-kinase by fasudil contributes to the modulation of the synaptic plasticity response in the rat hippocampus.

Pflugers Arch. 2025 Jun;477(6):787-796. doi: 10.1007/s00424-025-03078-4. Epub 2025 Apr 12.

Molecular signaling predicts corticospinal axon growth state and muscle response plasticity induced by neuromodulation.

Proc Natl Acad Sci U S A. 2024 Nov 19;121(47):e2408508121. doi: 10.1073/pnas.2408508121. Epub 2024 Nov 13.

Circular RNAs in Cell Cycle Regulation of Cancers.

Int J Mol Sci. 2024 May 31;25(11):6094. doi: 10.3390/ijms25116094.

Pten knockout in mouse preosteoblasts leads to changes in bone turnover and strength.

JBMR Plus. 2024 Jan 4;8(3):ziad016. doi: 10.1093/jbmrpl/ziad016. eCollection 2024 Feb.

Unraveling the Impact of Intratumoral Heterogeneity on EGFR Tyrosine Kinase Inhibitor Resistance in -Mutated NSCLC.

Int J Mol Sci. 2023 Feb 18;24(4):4126. doi: 10.3390/ijms24044126.

PTEN checkMAITs type-17 innate-like T cells.

Nat Cell Biol. 2022 Nov;24(11):1565-1567. doi: 10.1038/s41556-022-01012-9.

Signal Transduction Regulators in Axonal Regeneration.

Cells. 2022 May 4;11(9):1537. doi: 10.3390/cells11091537.

A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A.

RSC Adv. 2018 Apr 12;8(25):13747-13749. doi: 10.1039/c8ra02052c. eCollection 2018 Apr 11.

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.

Int J Mol Sci. 2021 Jan 25;22(3):1171. doi: 10.3390/ijms22031171.

Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review.

Front Oncol. 2020 Dec 10;10:610923. doi: 10.3389/fonc.2020.610923. eCollection 2020.

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

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The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

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