Bornstein J D, Cohn J A
Duke University Medical Center, Box 3378, Durham, NC 27710, USA.
Curr Gastroenterol Rep. 1999 Apr;1(2):161-5. doi: 10.1007/s11894-996-0016-6.
Idiopathic chronic pancreatitis accounts for up to one third of chronic pancreatitis cases. The most common inherited disease of the exocrine pancreas is cystic fibrosis, which is caused by mutations of a gene encoding an ion transport protein. It was discovered during the past year that many patients with idiopathic chronic pancreatitis have mutations of the gene that causes cystic fibrosis. This article reviews the evidence associating mutations of this gene with chronic pancreatitis and discusses the implications of this association for the evaluation, pathogenesis, classification, and possible prevention of pancreatitis.
特发性慢性胰腺炎占慢性胰腺炎病例的三分之一。胰腺外分泌最常见的遗传性疾病是囊性纤维化，它由编码离子转运蛋白的基因突变引起。在过去一年中发现，许多特发性慢性胰腺炎患者存在导致囊性纤维化的基因突变。本文综述了该基因突变与慢性胰腺炎相关的证据，并讨论了这种关联对胰腺炎评估、发病机制、分类及可能的预防措施的影响。
