Fennerty M B
Division of Gastroenterology-PV310, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201, USA.
Curr Gastroenterol Rep. 1999 Jun;1(3):210-3. doi: 10.1007/s11894-999-0036-0.
Barrett's esophagus is a premalignant lesion of the esophagus that arises as an abnormal tissue response to epithelial injury from gastroesophageal reflux. Barrett's esophagus has previously been considered an irreversible lesion that required life-long surveillance to prevent malignant transformation. Recently, combination therapy with pharmacologic or surgical control of acid reflux combined with endoscopic delivery of a mucosal injury appears to have the capability of reversing superficial Barrett's tissue, and perhaps deeper tissue as well. Whether Barrett's esophagus is cured and cancer/dysplasia prevented by these techniques will require long-term follow-up of these patients.
巴雷特食管是食管的一种癌前病变，它是对胃食管反流引起的上皮损伤的一种异常组织反应。巴雷特食管以前被认为是一种不可逆的病变，需要终身监测以预防恶变。最近，采用药物或手术控制胃酸反流并结合内镜下造成黏膜损伤的联合治疗似乎有能力逆转浅表的巴雷特组织，甚至可能逆转更深层的组织。这些技术能否治愈巴雷特食管并预防癌症/发育异常，还需要对这些患者进行长期随访。
