Leclercq-Meyer V, Rebelledo O, Marchand J, Malaisse W
Science. 1975 Sep 12;189(4206):897-9. doi: 10.1126/science.1098149.
During calsium deprivation, the rate of glucagon release by the isolated perfused rat pancreas is positively related to the glucose concentration of the perfusion medium. It is suggested that such a paradoxical behavior, which is reminiscent of the abnormality of glucagon secretion recently disclosed in diabetic subjects, results from a perturbation in the normal structural and functional bridging between pancreatic alpha and beta cells.
在钙缺乏期间，离体灌注大鼠胰腺释放胰高血糖素的速率与灌注液中的葡萄糖浓度呈正相关。有人认为，这种自相矛盾的行为类似于最近在糖尿病患者中发现的胰高血糖素分泌异常，是由胰腺α细胞和β细胞之间正常结构和功能联系的紊乱所致。
